Relaxivity on Contrast Agents

In addition to protein dynamics investigation, relaxivity measurement on contrast agents is also a hot topic in NMR relaxometry studies. Relaxivity measurement is also a field-dependent relaxation measurement but observing on the solvent side. Its important application as contrast agents in MRI. The agents perturb the relaxation mechanism in water to increase the imaging contrast in the region of interest.
Our field-cycler has been utilized in such studies and opened a comparable magnetic field range of relaxivity measurement as current MRI scanners.

Scientific Reports 7, Article number: 44770 (2017) doi:10.1038/srep44770

In Vivo Field-Cycling Relaxometry Using an Insert Coil for Magnetic Field Offset. Magnetic Resonance in Medicine 72(5) DOI: 10.1002/mrm.25040