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What is Field-Cycling NMR?

time profile of field cycling

Field-cycling NMR (Nuclear Magnetic Resonance) is a technique that involves changing the magnetic field strength during an NMR experiment. In traditional NMR, a constant magnetic field is applied to the sample, causing the nuclei in the sample to resonate at a specific frequency. By detecting the resonance frequency, we can learn about the sample's chemical and physical properties. In field-cycling NMR, the magnetic field is periodically varied over a range of strengths, causing the sample's resonant frequency to change as well. This allows for the observation of additional information about the sample, including its relaxation properties and interactions with the surrounding environment.

Special instruments required for Field-Cycling NMR

Our High-Field Field-Cycler (HFFC) is a rapid sample shuttler that integrates directly with commercial high-field NMR spectrometers. It transports the NMR sample swiftly between stray-field positions and the acquisition center, enabling relaxation dispersion measurements across a wide field range, while fully preserving the resolution and sensitivity of your high-field system.

High field relaxometry sample shuttling mechanism animation

What is illuminated NMR?

Illuminated Nuclear Magnetic Resonance (NMR) merges NMR spectroscopy with light, offering a powerful tool for chemical analysis and optogenetic engineering. Notably, Photo-CIDNP (Chemically Induced Dynamic Nuclear Polarization) enhances NMR signal strength by transferring energy from light-activated photosensitizers to target nuclei. This technique unlocks insights into radical reactions, molecular dynamics, and hidden reaction pathways, revealing the fascinating world of molecular behavior under light's influence.

time profile of illumination during the NMR experiment

Special instruments required for illuminated NMR

In-situ illuminated NMR: Animation of the compact photo-CIDNP module for fixed-field NMR spectrometers.

We have designed two specialized illuminator models designed to integrate with commercial high-field NMR spectrometers.

The first model, the high-field illuminator, facilitates sample irradiation within the commercial high-field NMR spectrometer's sweep spot.

Field-cycling photo-CIDNP: Animation of the illumination system for variable-field NMR studies.

The second model, the Field-Cycling NMR Illuminator, delivers non-contact optical excitation directly to the sample at variable stray-field positions inside the spectrometer. Its fiber-free design eliminates mechanical interference during shuttling, allowing the sample to move rapidly and precisely between the illumination spot and the acquisition position. This shuttle-illumination module is an exclusive add-on to the High-Field Field-Cycler (HFFC).

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